Historical
EP14-A2
Evaluation of Matrix Effects; Approved Guideline - Second Edition
Clinical and Laboratory Standards Institute (CLSI) document EP14-A2 - Evaluation of Matrix Effects; Approved Guideline - Second Edition was developed for manufacturers, regulators, and providers of proficiency testing or external quality assessment programs, although it will be useful to clinical laboratories as well. The document will help users to determine whether matrix programs, although it will be useful to clinical laboratories as well. The document will help users to determine whether matrix effects are the source of unexpected results that are sometimes observed with processed samples when two measurement procedures are compared; to identify and quantify the magnitude of the effects; and to ensure that laboratory performance is evaluated fairly if matrix effects are present. The suggested protocols were developed using patient specimens as the standard of comparison. A list of definitions is included.
Clinical And Laboratory Standards Institute [clsi]